Evolvability of cancer-associated genes under APOBEC3A/B selection

Evolvability of cancer-associated genes under APOBEC3A/B selection

Blog Article

Summary: Evolvability is an emergent hallmark of cancer that depends on intra-tumor heterogeneity and genetic variation.Mutations generated by Bags - Reclosable Bags APOBEC3 contribute to genetic variation and tumor evolvability.However, the influence of APOBEC3 on the evolvability of the genome and its differential impact on cancer genes versus non-cancer genes remains unclear.Analyzing over 40,000 human protein-coding transcripts, we identified distinct distribution patterns of APOBEC3A/B TC motifs between cancer and non-cancer genes, suggesting unique associations with cancer.

Studying a bat species with numerous APOBEC3 genes, we found distinct motif patterns Family Games in orthologs of cancer genes compared to non-cancer genes, as in humans, suggesting APOBEC3 evolution to reduce impacts on the genome rather than the converse.Simulations confirmed that APOBEC3-induced heterogeneity enhances cancer evolution through bimodal patterns of mutations in certain classes of genes.Our results suggest the bimodal distribution of APOBEC-induced mutations can significantly increase cancer heterogeneity.